Enoxaparin antidote1/7/2023 ![]() Note that each direct factor Xa inhibitor has the letters “Xa” in its spelling. The DOACs act directly upon Factors IIa (DTIs) or Xa (“Xabans”) without using antithrombin as a mediator. ![]() Examples of DOACs include the following: direct thrombin inhibitors (DTIs) dabigatran (Pradaxa) and direct factor Xa inhibitors (“Xabans”) rivaroxaban (Xarelto), apixaban (Eliquis) and edoxaban (Lixiana, Savaysa). Target-specific oral anticoagulants (TSOACs) or direct oral anticoagulants (DOACs) were developed to provide more stable pharmacokinetic and pharmacodynamic options for oral anticoagulation. VKAs reduce the synthesis of factors II, VII, IX and X thereby reducing ability to generate active thrombin, rather than inhibition of activated enzymes. Once an injectable indirect factor Xa and IIa inhibitor has been selected, an oral vitamin K antagonist (VKA), traditionally warfarin (Coumadin), is started on the same day. Finally, Fondaparinux (Arixtra) is an exclusive indirect factor Xa inhibitor. Enoxaparin (Lovenox), a low-molecular-weight-heparin (LMWH), inhibits factors Xa and to a lesser extent IIa. UFH also inhibits factors XIIa, XIa and IXa. Examples of injectable indirect factor Xa and IIa inhibitors include unfractionated heparin (UFH), which inhibits factors Xa and to a lesser extent IIa. ![]() Physicians have numerous anticoagulation treatment options in their arsenal including the traditional injectable indirect factor Xa and IIa (thrombin) inhibitors, which are mediated through an antithrombin dependent mechanism.
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |